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In vitro serial dilution tests have shown that the spectrum of antibacterial activity of sulfamethoxazole and trimethoprim injection includes common bacterial pathogens with the exception of Pseudomonas aeruginosa.
The following organisms are usually susceptible: Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis, indole-positive Proteus species including Proteus vulgaris, Haemophilus influenzae (including ampicillin-resistant strains), Streptococcus pneumoniae, Shigella flexneri and Shigella sonnei.
The presence of 10 mg percent sulfamethoxazole in plasma decreases the protein binding of trimethoprim by an insignificant degree; trimethoprim does not influence the protein binding of sulfamethoxazole.
Excretion of sulfamethoxazole and trimethoprim is primarily by the kidneys through both glomerular filtration and tubular secretion.
The principal metabolites of trimethoprim are the 1- and 3-oxides and the 3'- and 4'-hydroxy derivatives.
BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Use the following data: Multiples of 80mg/ 125 ml fluid - 6hr stability [ concentration: 0.64 mg/m L] 80mg/100ml - 4hr stability [ concentration: 0.8 mg/m L] Min dilution - 80 mg/75 ml - 2 hr stability [ concentration: 1.07 mg/m L] Example: 375mg/500m L [Conc = 0.75 mg/m L] Estimated stability ~ 4 hrs (rounding concentration to 0.8 mg/m L) Label: Do not Refrigerate Minimum dilution: 80 mg TMP/ 75 ml.
Non-PCP: 10mg/kg/day ( based on TMP component) divided q6h or q8h or q12h.
In an established infection, they will not eradicate the streptococcus and, therefore, will not prevent sequelae such as rheumatic fever.
Pseudomembranous colitis has been reported with nearly all antibacterial agents, including SMX and TMP injection, and may range in severity from mild to life-threatening.
PCP: 15-20mg/kg/day (based on TMP component) divided q6h.